DETAILS, FICTION AND PKRRATING

3B). R526 through the loop involving αJ and αI anchors the C-terminal percentage of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the leading chain carbonyl of R413. The suggestion from the activation segment is stabilized by a hydrogen bond amongst Y454 and E480